On Thursday, November 5, 2009 2:14 PM, bagher mohammadpour <bmp1337@yahoo.com> wrote to:
bessi@icepharma.is <bessi@icepharma.is>;
actavis@actavis.com <actavis@actavis.com>;
jjonsson@actavis.is <jjonsson@actavis.is>;
adougherty@medis.is <adougherty@medis.is>;
jgray@medis.is <jgray@medis.is>;
ncleator@medis.is <ncleator@medis.is>;
kschrauwen@medis.is <kschrauwen@medis.is>;
stuartc@medis.is <stuartc@medis.is>;
Bagher Mohammad Pour
(Pharmacist)
ADDRESS:
Mr Ossan Awad
(For Mr Bagher Mohammad pour)
24 Bd de la chapelle,
75018 Paris,
75018 Paris,
France.
Dear Mr Bessi H Jóhannesson
Director Pharmaceuticals Division
1-I am an Iranian pharmacist. From Tabriz university in Iran I received my Pharm. D. degree at the beginning of 1985. I have spent all my professional life in service of the pharmaceutical industries of Iran. From the very first weeks I faced a lot of huge scientific and practical mistakes in all aspects of production of medicinals. Unfortunately leaving a company and joining another only changed my mistrust in inadequacy of theoretical and practical arrangements into an absolute faith in existence of a nationwide disaster in these industries. My DISASTROUS and incredible findings in every company put them in danger of a devastating earthquake with unpredictable consequences not only for themselves but for MoH who carried all and also the final responsibility of everything industries did & DO. So I always forced to move (actually I was dismissed) to another company and repeating the same story. The simplest cases of those mistakes deserve up to few million dollars of fine and about ten years jail in the U.S.A. and Europe. The recent case of Pfizer ( http://www.nytimes.com/2009/09/03/business/03health.html ) with 2300 million $ of fine is the best evident on the severity of the case of Iran.
2- On 29,09,2006 I entered Paris for an international exhibition on pharmaceutical materials. In hope of finding a solution for that crisis I stayed there but failed to gain any support to divulge this absolute case of Human Rights violation. In France I received tow negatives and after about twenty seven months decided to go back to Iran. In Vienna airport I experienced an intolerable phobia (because of all those horrible experiences I have) and lost my flight. In hope of finding a solution I applied in Austria again but as in France I received tow negatives. By the rule of “No one can believe what he does not understand”, I asked in both countries my claims and documents be evaluated by experts but they disregarded this legal request and till now no experts has studied and evaluated my documents and by law they disregarded my request against the law. As J. S. Mill says:Very few facts are able to tell their story without comments to bring out their meaning. All my claims about this crisis are based on a lot official documents from different pharmaceutical companies and the Ministry of Health.
3-During all of my professional life, somehow I was the best between my colleagues. All information and documents by help of them I discovered all those huge mistakes were also available to them but no one detected and noticed even one of those huge mistakes. Successful and important improvements in nearly all aspects of pharmaceutical industry also include in my professional background. Opportunities for exercising habit of critical thinking and the exceptional capacity in application of creativity tied me strongly to my job in spite of depriving from all legitimate economical and social benefits. Considerable studies in Management, Organization, Organizational behavior, Ergonomy, Sociology, Social psychology, Psychology, Cognitive psychology, Educational and Learning Psychology, Philosophy and Philosophy of Education provided me a nearly reliable mental awareness and critical mind.
4-And this letter is my request from you and your country to be accepted and supported as a refugee OR as an independent educated immigrant who is not only able to afford his life but can manage perfectly well on his own.
I greatly hope your kindness and humanistic interests will afford protection to me and prevent me from going back again to that absolute HELL on the earth. The dark side of life in Iran could not be completely understood without living there and unfortunately I have lived the worst hidden parts of it during the last twenty and five years and have lost all my moral and psychological capacities to be there again. My sincere request is to be protected from the HELL in this World. Following up the crisis of the pharmaceutical system will completely depend on the preferences and will of your country. My professional background and experience would prove useful to you pharmaceutical and chemical industries of your country.
Following the horrible life in Iran I lost the last three years (in hope of the assistance of the founders of Human Rights but...!!!) and at the moment I live a hard life without any support from the French government. I hope to gain the support of you and your country soon to experience a better life and be able to work and present technical and scientific services to human beings for a happier and more healthier life.
I am eagerly looking forward to hearing from you as soon as possible and at the end my final request is that to be informed from your decision even it be not in favor of my request: for all those reason life has put forward.
Sincerely yours
B Mohammad Pour
"MY CV, MY CV, MY CV, MY CV, MY CV"
MOHAMMAD POUR, BAGHER (Male, PHARM. D.)NO 32, BARZEGARPOUR LANE,
HKOSH ST.,
MORTAZAVI CROSS,
TEHRAN 13547,
IRAN.bmp1337@yahoo.com
HKOSH ST.,
MORTAZAVI CROSS,
TEHRAN 13547,
IRAN.bmp1337@yahoo.com
(At the moment I am in Paris)
PERSONAL DETAILS:
FAMILY NAME: MOHAMMAD POUR
NAME: BAGHER
DOB: 30/04/1958
POB: TEHRAN/IRAN
NO OF ID CARD: 2047
FATHER: MOHAMMAD HOSSEIN
MARRAGE: DIVORCED
CHILDREN: MOHAMMAD; 20 YEARS OLD; TEHRAN/IRAN; UNIVERSITY STUDENT OF PHYSICS IN TEHRAN.EDUCATION:
1-HIGHSCHOOL DIPLOMA: 1976, NATURAL SCIENCES
2-UNIVERSITY DIPLOMA: PHARM. D.; TABRIZ UNIVERSITY, TABRIZ, IRAN; 1976-1985 (INCLUDING REVOLUTION & CULTURAL REVOLUTION OFF-DAYS)
3-OTHERS: ISO 9000 SERIES, TWO COURSES: 1-STRUCTURE & DEVELOPMENT, 2-QUALITY MANAGEMENT AUDITOR.PROFFESSIONAL BACKGROUND:
1-APR 1985-JUL 1986; RAZAK PHARMA CO, MANAGER OF PACKING DEPT.
2-JUL 1986-NOV 1988; EMERGENCY MILLITARY SERVICE.
3-MAR 1986-NOV 1990; MANDATORY SERVICE FOR MOH.
4-JAN 1991-AUG 1992; ALBORZ DAROU PHARM CO, MANAGER OF LIQUID DEPT.
5-JAN 1993-OCT 1994; PHARMA CHIMIE; R&D DEPT. MANAGER.
6-OCT 1994-SEP 1995; PYRAIEH COSMETIC & HYGIENIC CO; RESPONSIBLE PHARMACIST.
7-DEC 1995-JAN 1997; LOGHMAN PHARM CO; PRODUCTION MANAGER.
8-NOV 1997-VOV 1999; ALHAVI PHARM CO; PRO- DUCTION MANAGER.
9-JUN 2000-JUN 2001; TEHRAN DAROU PHARM CO;
RESPONSIBLE PHARMACIST.
10-SEP 2002-DEC 2006; SHAHRE DAROU PHARM CO;
LIQUID PRODUCTION MANAGER; the last position:
QC MANGAER for more than three years.ACHIEVEMENTS:A NECESSARY INTRODUCTION: Because of my special interests in nearly all aspect of pharmaceutical production, always I was involved in many different kind of professional and scientific activities. At the same moment there were two others reason for the diversity of my interests and engagement in different aspect of pharmaceutical production. The first reason is that any kind of industrial production is an integrated chain and steps of different activities that form, or MUST form a logical sequence of tasks in each, the previous step object is the initial material for the next: thus the successful result or end of each step MUST be evaluated on, first, the quality of initial material (as defined above) and, second, the correctness of the next step activity AND its proper and successful exercise. So, under the light of the mentioned principle, I was always aware that detection of the nature of each single activity OR problem depends totally and absolutely
on our understanding of all the production procedure as a Single and Unified Activity, and secondly without having a clear mental map and theoretical understanding of what WE are doing, neither we could evaluate the correctness of each step achievement nor we would be able to Detect, Define, and solve our problems. This was the first reason of my notice to and interest in different fields of pharmaceutical production from QC of materials to Formulation and Process Design up to the definitions of quality parameters and the methods of their assessment.
And on the basis of my understanding and familiarity with the educational deficiencies in universities, and more importantly, the gross dependence and reliance of Pharmaceutical industry as a branch of Chemical Industry on Natural Sciences, I have tried to compensate what educational system was never able to provide, AND KNOWING THAT without a basic understanding of them nothing could be done without a gross inclusion of errors and fatal mistakes, I tried, as far as I could, to Absorb what I needed as an Industrial pharmacist, what usually none of my colleagues could provide me as a pharmacist and colleague. For example, my first official position as QC manager was in Shahre Darou but I was the main participant of QC lab in Alhavi or in Alborz Darou, and as the manager of Production my engagement in understanding all possible scientific or technical basis of our activity was clear, deep, and firm. This can be believed noticing the diversity of my
activities and corrections which spread from too early initial step of Water System up to designing and writing the most com-prehensive and practical and Scientific based Analytical Procedure FOR QC Laboratory and up to Stability and Organoleptic properties of medicinals. Two principles have always guided my professional life, from biology and manage- ment: Nature Does Nothing for Nothing (We need have reasons for our choices) & Always There Could Be a Better Way (We must keep our mind open to new ideas and to the future). Therefore all the below cases are the fruits of one or both of the above Principles.
Here I could not provide a complete list of my activities nor I could provide necessary convincing information on them. This list only mentions the core and heart of the problems without necessarily any notice to the company and some time out of historical order and under the force of limited time. (a late contemporary Iranian poet says: And suddenly/ Very soon/ It becomes late; Ghaisar-e Amin Pour.)A SHORT LIST OF ACHIEVEMENTS
1)Correction of many mistakes in different laboratory control methods of Raw Materials and finished products in many companies; mistakes up to fifty percent, and usually more, could not be detected or could be introduced.
2)Mixing of raw well water with syrups after too many years prevented and it was because of a design defect in the filling machine.
3)Correction of a totally wrong manufacturing procedure reduced the manufacturing time of a pediatric liquid antibiotic from ten hours in tow days to three hours in one day and consequently production capacity of that production increased 600%. A further correction of its formulation reduced its excipients about 1300 kg per 3000 Liter (And scientific proof for the former procedure being mistake and justification of correctness of the new were totally based on the best texts of the time.) Its bitter taste and disgusting smell and taste and permanent default of undispessed agglomerates vanished for ever.
4)Defect in installation of a washing machine led to remaining about two milliliters of an extremely concentrated Chlorine water in the washed bottles used for bottling the above mentioned pediatric antibiotic suspension.
5)Usage an totally Inactive microbial preservative in an antacid suspension corrected after too many years and by the aid of the most basic principles of chemistry and biology an active one selected.
6)Active ingredients of an antacid suspension and tablets were respectively 25% and 16% less than the label amounts in at least two company and for an unknown time; I corrected them.
7)In a comprehensive report, in more than one hundred pages, I proved that nearly what I knew till then in that company were wrong to the strongest and widest meaning of the word of wrong and provided detailed comments on all of them in three field: Production, QC, and Management.
8)Correction of filtering technique of a sugar syrup prevented the entrance of a considerable amount of any kinds of particles into a pediatric antibiotic suspension.
9)My comprehensive analysis (in about two hundred pages), as the Responsible Pharmacist, of seven files on design, production, and QC procedures of six important medicines (some were life-saving) proved that they were ABSOLUTLY wrong in the strongest meaning of the word.
10)Correction of design of entrance of the main water reservoir of a company prevented entrance of washings and rain water in it and it continued for an unknown period of time
11)Correction of an administrative procedure reduced the usage of plastic spoons and aluminum caps up to 25%.
12) Correction of water purifying system where the saline water for regeneration of ion-exchanging resins was prepared in old and oxidized iron container and was dark-brown by plentifullnes of Ferric Oxide.
1)Correction of many mistakes in different laboratory control methods of Raw Materials and finished products in many companies; mistakes up to fifty percent, and usually more, could not be detected or could be introduced.
2)Mixing of raw well water with syrups after too many years prevented and it was because of a design defect in the filling machine.
3)Correction of a totally wrong manufacturing procedure reduced the manufacturing time of a pediatric liquid antibiotic from ten hours in tow days to three hours in one day and consequently production capacity of that production increased 600%. A further correction of its formulation reduced its excipients about 1300 kg per 3000 Liter (And scientific proof for the former procedure being mistake and justification of correctness of the new were totally based on the best texts of the time.) Its bitter taste and disgusting smell and taste and permanent default of undispessed agglomerates vanished for ever.
4)Defect in installation of a washing machine led to remaining about two milliliters of an extremely concentrated Chlorine water in the washed bottles used for bottling the above mentioned pediatric antibiotic suspension.
5)Usage an totally Inactive microbial preservative in an antacid suspension corrected after too many years and by the aid of the most basic principles of chemistry and biology an active one selected.
6)Active ingredients of an antacid suspension and tablets were respectively 25% and 16% less than the label amounts in at least two company and for an unknown time; I corrected them.
7)In a comprehensive report, in more than one hundred pages, I proved that nearly what I knew till then in that company were wrong to the strongest and widest meaning of the word of wrong and provided detailed comments on all of them in three field: Production, QC, and Management.
8)Correction of filtering technique of a sugar syrup prevented the entrance of a considerable amount of any kinds of particles into a pediatric antibiotic suspension.
9)My comprehensive analysis (in about two hundred pages), as the Responsible Pharmacist, of seven files on design, production, and QC procedures of six important medicines (some were life-saving) proved that they were ABSOLUTLY wrong in the strongest meaning of the word.
10)Correction of design of entrance of the main water reservoir of a company prevented entrance of washings and rain water in it and it continued for an unknown period of time
11)Correction of an administrative procedure reduced the usage of plastic spoons and aluminum caps up to 25%.
12) Correction of water purifying system where the saline water for regeneration of ion-exchanging resins was prepared in old and oxidized iron container and was dark-brown by plentifullnes of Ferric Oxide.
13)Granulating procedure of an antibiotic tablet was totally unjustified and wrong so dried granules were completely incompressible and pressing were divided into many small time-consuming and hard steps and finally lead to extremely fragile and rough surface tablets.
14)Application the simplest rules of Algebra and Arithmetic proved that nearly all QC calculations are wrong and interpretation of results were arbitrary and had no scientific basis or support in the eyes of International Authorities like FDA and...
15)As a responsible person in a hygienic company I did a vast investigation on formulation of Dishwashing Liquids and to a great extent discovered none knew the exact scientific basis of making a chemically (at least) justified product and usually the mixing order of components were wrong so unwanted chemical reaction between those that had not to bear it, lead to destruction of chemicals and a production of unknown components with unpredictable
activity and side effects. That article is available.
16)Correction of preparation method of a cellulosic gum increased its viscosity 300% and reduced its usage to one-third.
17)Investigation of spectroscopic method of analysis in USP proved that it was (and ‘is’ till today) incomplete and BP provided no method; even the USP method requires you the answer to be able to solve your problem!! I find a very simple and extremely useful formula to complete USP method and removed its logical controversy. Further examination of that formula showed that it can be used successfully in designing in-home methods of spec- troscopic measurements and make us able to do what we want by positive application of our limitations and possibilities. The reply of the Chief Editor of that part of USP was the strangest possible by a USP’s Editor:
We do not have time to study your formula and letter.
18)In reply to request of a General Manager I wrote a detailed report on nearly all aspect of the life of that organization. In that letter I proved scientific mistakes had invaded all era of Organizational Life and quality is Accidental and Unintentional. That letter contains about fifty comments on all aspects, directly or indirectly, quality both as an activity or a goal and, the importance of production as the heart of an industrial unit. In another activity I corrected the analytical methods of the following materials with the stated percentage of errors:
MgO, minus 40%; Fe Fum., plus 900%; assay test of a Decongestant in a syrup, minus 92.5 in one respect and plus 1250% in another; Ca(ion) in a capsule minus 100%. And too many others, for example wrong adjustment of a Colloid Mill lead to destruction of about 200,000 bottles of Chloramphenicol suspension.
19)Stabilization of an extremely unstable Ferrous solution in a new formulation and reducing its Coloring effect on teeth.
20)Designing and improving many technical forms of production, QC laboratory, and administrative department by: Application of similarity in similar forms; Canceling unrelated information and/or items; Inclusion of necessities; and Finally adaptation of their design and follow with the administrative procedures and require- ments of GMP, ISO, and Internal Design of organization. Importance of this principle has made it a feature and criteria of suitability of organizations by this formula:
Structure and efficiency of a well-designed organization,
And the competence of its creators ,
are defined in, and mirrored by its FORMS respectively.
(in other words: good FORMS are self-defining and the best guidance and MAP on your location in the organization.) Many forms by application of this principle were corrected.
21)Application of ‘USP Introduction’s recommendation, or what can be even interpreted as ORDER ,on the Necessity of Internalizing and Absorption of scientific basis of each test and monograph, proved that by simple translation of them into the mother-tongue of technicians and rewriting or typing them in a tidy format nearly Nothing of knowledge would be gained and no responsibility would be fulfilled, and brings not even a small portion of practical efficiency and expert: Any activity in the filed of application of Natural Sciences, in their most modern meaning of them, without bearing a Good and Deep understanding of their theoretical ground in mind, is Only and Only a ‘sleepwalking’ and sleepwalker fells and stops very soon by the first obstacle.
Some sample were done. All the above huge mistakes in analytical procedures and results were the fruits of ignorance to that order and its importance and were solved only ay its application. Those samples proved that in some cases the Supporting Information of an analysis could be up to ten times of its text and need a lot of references be used at the same time.
MORE POINTS ON PERSONAL INTERESTS:
1)My personal library has about three thousand volumes of books. They could be divided into two main category; first books on Human sciences and second those on Natural sciences. Some books in the former part have some applications on organizations and by this way find some links to environmental parameters of scientific
Of human society; for example principles of philosophy, psychology, sociology, management or even politics and some concepts of biology have strong applications in organizations and through this way could help in understanding of those specific problems which have been a constant part of human life in society and history.
2)My Natural Sciences books are on the subjects: Physics (as the king, head and spring of all other discipline in this field), Calculus, Linear Algebra, Geometry, Statistics, Pharmaceutical statistics, Statistical design, Thermodynamic, General chemistry, Organic chemistry, Inorganic chemistry, Medicinal chemistry, Pharmaceutical chemistry, Physical chemistry, Instrumental analytical chemistry, Unit operations in chemical engineering, Perry’s handbook of chemical engineering, Engineering and mechanical design, Industrial pharmacy(many), Pharmacology: Basic, Clinical, Molecular; Drug information, Internal medicine, Biopharmaceutics, Pharmacokinetics, Quality control, Statistical quality control, GMP regulations, and …
3)My Human sciences books on related fields to Organizations are on subjects: Sociology, Psychology, Social psychology, Management, Organizational Behavior,
Organization design, Ergonomy, Job design, ISO applications and …
4)My main interest is reading and reading and reading, and then Hiking, Photography, Handicraft, Persian Poem and Language and Vocabulary and Prose style; English language (more than two hundred books on different aspect of English language including about sixty volume monolingual English-English dictionaries of different kinds and size and publishers).
5)This letter is the example of my writing ability in English and, my speaking is nearly at the same level and I have no difficulty in reading, understanding and interpretation of scientific and pharmaceutical texts and references.
B Mohammad pour
Pharm. D.
May 2009.
14)Application the simplest rules of Algebra and Arithmetic proved that nearly all QC calculations are wrong and interpretation of results were arbitrary and had no scientific basis or support in the eyes of International Authorities like FDA and...
15)As a responsible person in a hygienic company I did a vast investigation on formulation of Dishwashing Liquids and to a great extent discovered none knew the exact scientific basis of making a chemically (at least) justified product and usually the mixing order of components were wrong so unwanted chemical reaction between those that had not to bear it, lead to destruction of chemicals and a production of unknown components with unpredictable
activity and side effects. That article is available.
16)Correction of preparation method of a cellulosic gum increased its viscosity 300% and reduced its usage to one-third.
17)Investigation of spectroscopic method of analysis in USP proved that it was (and ‘is’ till today) incomplete and BP provided no method; even the USP method requires you the answer to be able to solve your problem!! I find a very simple and extremely useful formula to complete USP method and removed its logical controversy. Further examination of that formula showed that it can be used successfully in designing in-home methods of spec- troscopic measurements and make us able to do what we want by positive application of our limitations and possibilities. The reply of the Chief Editor of that part of USP was the strangest possible by a USP’s Editor:
We do not have time to study your formula and letter.
18)In reply to request of a General Manager I wrote a detailed report on nearly all aspect of the life of that organization. In that letter I proved scientific mistakes had invaded all era of Organizational Life and quality is Accidental and Unintentional. That letter contains about fifty comments on all aspects, directly or indirectly, quality both as an activity or a goal and, the importance of production as the heart of an industrial unit. In another activity I corrected the analytical methods of the following materials with the stated percentage of errors:
MgO, minus 40%; Fe Fum., plus 900%; assay test of a Decongestant in a syrup, minus 92.5 in one respect and plus 1250% in another; Ca(ion) in a capsule minus 100%. And too many others, for example wrong adjustment of a Colloid Mill lead to destruction of about 200,000 bottles of Chloramphenicol suspension.
19)Stabilization of an extremely unstable Ferrous solution in a new formulation and reducing its Coloring effect on teeth.
20)Designing and improving many technical forms of production, QC laboratory, and administrative department by: Application of similarity in similar forms; Canceling unrelated information and/or items; Inclusion of necessities; and Finally adaptation of their design and follow with the administrative procedures and require- ments of GMP, ISO, and Internal Design of organization. Importance of this principle has made it a feature and criteria of suitability of organizations by this formula:
Structure and efficiency of a well-designed organization,
And the competence of its creators ,
are defined in, and mirrored by its FORMS respectively.
(in other words: good FORMS are self-defining and the best guidance and MAP on your location in the organization.) Many forms by application of this principle were corrected.
21)Application of ‘USP Introduction’s recommendation, or what can be even interpreted as ORDER ,on the Necessity of Internalizing and Absorption of scientific basis of each test and monograph, proved that by simple translation of them into the mother-tongue of technicians and rewriting or typing them in a tidy format nearly Nothing of knowledge would be gained and no responsibility would be fulfilled, and brings not even a small portion of practical efficiency and expert: Any activity in the filed of application of Natural Sciences, in their most modern meaning of them, without bearing a Good and Deep understanding of their theoretical ground in mind, is Only and Only a ‘sleepwalking’ and sleepwalker fells and stops very soon by the first obstacle.
Some sample were done. All the above huge mistakes in analytical procedures and results were the fruits of ignorance to that order and its importance and were solved only ay its application. Those samples proved that in some cases the Supporting Information of an analysis could be up to ten times of its text and need a lot of references be used at the same time.
MORE POINTS ON PERSONAL INTERESTS:
1)My personal library has about three thousand volumes of books. They could be divided into two main category; first books on Human sciences and second those on Natural sciences. Some books in the former part have some applications on organizations and by this way find some links to environmental parameters of scientific
Of human society; for example principles of philosophy, psychology, sociology, management or even politics and some concepts of biology have strong applications in organizations and through this way could help in understanding of those specific problems which have been a constant part of human life in society and history.
2)My Natural Sciences books are on the subjects: Physics (as the king, head and spring of all other discipline in this field), Calculus, Linear Algebra, Geometry, Statistics, Pharmaceutical statistics, Statistical design, Thermodynamic, General chemistry, Organic chemistry, Inorganic chemistry, Medicinal chemistry, Pharmaceutical chemistry, Physical chemistry, Instrumental analytical chemistry, Unit operations in chemical engineering, Perry’s handbook of chemical engineering, Engineering and mechanical design, Industrial pharmacy(many), Pharmacology: Basic, Clinical, Molecular; Drug information, Internal medicine, Biopharmaceutics, Pharmacokinetics, Quality control, Statistical quality control, GMP regulations, and …
3)My Human sciences books on related fields to Organizations are on subjects: Sociology, Psychology, Social psychology, Management, Organizational Behavior,
Organization design, Ergonomy, Job design, ISO applications and …
4)My main interest is reading and reading and reading, and then Hiking, Photography, Handicraft, Persian Poem and Language and Vocabulary and Prose style; English language (more than two hundred books on different aspect of English language including about sixty volume monolingual English-English dictionaries of different kinds and size and publishers).
5)This letter is the example of my writing ability in English and, my speaking is nearly at the same level and I have no difficulty in reading, understanding and interpretation of scientific and pharmaceutical texts and references.
B Mohammad pour
Pharm. D.
May 2009.
No comments:
Post a Comment